Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
Sample Processing in Laboratory
Usual
Sample Preparation
Centrifuge
Turnaround Time
1 daySample Stability
Usual. Samples are stable for 7 days when stored at 4˚C or for up to 1 year if stored at -20˚C
Gamma Glutamyl Transferase (GGT)
General Information
Gamma-glutamyl transferase (GGT) is an enzyme which is found in hepatocytes and biliary epithelial cells. Measurement of its activity provides a sensitive indicator of hepatobiliary disease although it is of no value in distinguishing between cholestatic or hepatocellular disease. In biliary obstruction, serum GGT activity may increase before that of ALP. Raised GGT levels have been reported in a variety of clinical conditions including:
- pancreatic disease
- myocardial infarction
- chronic obstructive pulmonary disease
- renal failure
- diabetes
- alcoholism
Drugs such as phenytoin and barbiturates may cause high GGT levels due to enzyme induction.
The reported sensitivity of a raised GGT for detecting alcohol ingestion has ranged from 52% to 94%.
Patient Preparation
None
Notes
Haemolysis interferes with this assay. No significant interference from high bilirubin or lipaemia.
Anticonvulsants, barbiturates, alcohol can increase GGT activity.
Reference Range
12-64 IU/L (Males)
9-36 IU/L (Females)
Source : Abbott Diagnostics
Specifications
- EQA Scheme?: Yes
-
EQA Status:
NEQAS and WEQAS