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HEFT Directorate of Pathology Blog

Welcome to the Directorate of Laboratory Medicine blog. Here you will find all the latest news and informaiton relevant to the directorate and its services.

 

 

New Drugs of Abuse Assay User Notification

on Thursday, 20 March 2025. Posted in Biochemistry

As of 25th March 2025 we will be introducing a new assay for drugs of abuse which will cover a wider repertoire of drugs and will now include some prescription drugs that are commonly abused.

The new assay will use a high resolution accurate mass spectrometer to detect the following drugs:

Drug Class

Drugs

Opiates and opioids

Buprenorphine (+ metabolite), Codeine, Dihydrocodeine, Fentanyl (+ metabolite), Methadone (+ metabolite), 6-Monoacetylmorphine, Morphine, Oxycodone, Papaverine, Pethidine (+ metabolite) and Tramadol (+ metabolite).

Benzodiazepines

Alprazolam (+ metabolite), Bromazolam, Chlordiazepoxide (+ metabolite), Clobazam (+ metabolite),  Clonazepam (+ metabolite), Diazepam (+ metabolite), Etizolam, Flualprazolam, Flubromazolam, Flunitrazepam (+ metabolite), Lorazepam, Midazolam (+ metabolite), Nitrazepam (+ metabolite) and Temazepam (+ metabolite).

Amphetamines

Amphetamine, 2C-B, 2C-I, MDEA, MDMA (Ecstasy) (+ metabolite), MDPV, Mephedrone, Methamphetamine, Methylphenidate and Ritalanic acid.

Other

Cocaine (+ metabolite), Gabapentin, Ketamine (+ metabolite), Pregabalin, Promethazine, Quetiapine, Tetrahydrocannabinol metabolite (cannabis metabolite), Zaleplon, Zolpidem and Zopiclone.

Positive results represent concentrations of drugs above the European Workplace Testing Thresholds with the exception of benzodiazepines.  We have lowered the cut off for this class of drug to 10ug/L to increase the detection of benzodiazepines.

Bromazolam, Etizolam, Flualprazolam, Flubromazolam, THC-COOH glucuronide, Buprenorphine glucuronide and Norbuprenorphine glucuronide will be qualitative only.

We do not screen for barbituates, propoxyphenes, phencyclidine, LSD or methaqualones.

Drugs without a cut-off have been assigned one based on chemically similar compounds.

If you have any queries regarding this please contact the duty toxicologist on This email address is being protected from spambots. You need JavaScript enabled to view it. or 0121 424 1392.