Preferred Sample Type
Suitable Specimen Types
- Fluoride Oxalate
A minimum of 500 µl of plasma/serum is required.
Specimen Transport
First class postSample Processing in Laboratory
Place sample in toxicology rack.Sample Preparation
None requiredTurnaround Time
3 days.Sample Stability
Keep refrigerated. 4 degrees.Zopiclone
General Information
Zopiclone is a cyclopyrrolone derivative that has been utilized clinically as a hypnotic agent since 1994. A single nightly hypnotic dose for adults may range from 3.75 - 15 mg.
The adverse reactions with zopiclone therapy include nausea, dizziness, headache, anterograde amnesia and respiratory depression. Reversible renal failure has been reported.
Patient Preparation
No patient preperation required.
Notes
Please contact the laboratory if zopiclone measurement is required for therapeutic monitoring purposes.
Zopiclone measured by LC-MS/MS
Please note this assay is not currently UKAS accredited
Reference Range
Toxicity associated with zopiclone levels > 0.15 mg/L. (Schulz et al. Critical Care 2012, 16:R136).
Specifications
- EQA Scheme?: Yes
- EQA Status: LGC QUARTZ, LGC CLIN TOX