Preferred Sample Type
Suitable Specimen Types
- Serum
- CSF
Sample Processing in Laboratory
Usual to BHH and First Class Post to Reference LabTurnaround Time
15 daysVoltage Gated Calcium Channel (VGCC) Antibodies
General Information
The Lambert Eaton myasthenic syndrome (LEMS) is a form of myasthenia often associated with small cell lung carcinoma.
In ~50% of cases there is IgG mediated reduction in presynaptic voltage gated calcium channels. This gives rise to the description \"voltage-gated calcium channel (VGCC) antibodies.
Voltage-gated calcium channels mediate calcium influx in response to membrane depolarisation and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression. Their activity is essential to couple electrical signals in the cell surface to physiological events in cells. They are members of a gene superfamily of transmembrane ion channel proteins that includes voltage-gated potassium and sodium channels.
Notes
Lambert Eaton Myasthenic Syndrome
Reference Range
Supplied by Reference laboratory
0-45 pM negative
Specifications
- EQA Scheme?: No
- EQA Status: No EQA SCHEME Available