Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
Specimen Transport
First class postSample Processing in Laboratory
Place sample in toxicology rack.Sample Preparation
None requiredTurnaround Time
3 days.Sample Stability
Keep refrigerated. 4 degrees.Promethazine
General Information
Promethazine is a phenothiazine derivative that has been widely used since 1950 for its antihistaminic, antiemetic and sedative effects.
Adverse reactions to promethazine include drowsiness, extrapyramidal reactions, dizziness, tinnitus, ataxia, blurred vision, termor, anxiety, hysteria, hypotension and tachycardia or bradycardia. Overdosage can cause coma, convulsions, respiratory despression and circulatory failure. Physostigmine has been found to reverse may of these effects.
Patient Preparation
No patient preperation required.
Notes
Promethazine measured by HPLC-DAD.
Please note this assay is not currently UKAS accredited
Reference Range
High dose therapeutic use of promethazine associated with concentrations of up to 0.2 mg/L. Toxicity associated with concentrations > 1 mg/L. (Schulz et al. Critical Care 2012, 16:R136).
Specifications
- EQA Scheme?: Yes
- EQA Status: LGC QUARTZ, LGC CLIN TOX