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Department

Immunology
PLA2RS

Preferred Sample Type

Phospholipase A2 receptor antibody (PLA2r)

Suitable Specimen Types

  • Serum
4 mL

Turnaround Time

14 days

Sample Stability

Stored at 4C

Phospholipase A2 receptor antibody (PLA2r)

General Information

Phospholipase A2 receptor is the target autoantigen in idiopathic membranous nephropathy (IMN). Antibodies to PLA2r are found in up to 75% of patients with IMN naive to immunosuppression and can be used as a diagnostic marker for IMN. PLA2r antibodies are found to be high in active disease and low/normal in complete remission and can be used to monitor disease activity.

Patient Preparation

No special requirements

Reference Range

<14 = Negative
14-20 = Borderline
>20 = Positive

results between 3 and 19.9 will be tested via IFA test at UoB

Specifications

  • EQA Scheme?: Yes
  • EQA Status: Pilot scheme run through UK NEQAS Sheffield PRU