LIVAB
Preferred Sample Type
Suitable Specimen Types
- Serum
5-10 mL
Sample Processing in Laboratory
Usual
Sample Preparation
Usual
Turnaround Time
5 daysSample Stability
Stored at 4oC
Mitochondrial Antibody (AMA)
General Information
Some indications: Primary Bilary Cirrhosis
Patient Preparation
None
Notes
Anti-Mitochondrial Antibodies (AMA) are strongly associated with Primary Biliary Cirrhosis (PBC), although they can be seen in other autoimmune conditions such as rheumatoid arthritis, systemic sclerosis and chronic liver disease . Different types of AMA are described, based on antigen specificity, designated on a numeric basis: M1 to M9. The AMA associated with PBC is usually M2a or M2b. Not all can be typed by IIF.
Samples screened as positive are titred to give a quantitative result and further tested to confirm presence of M2 antibody by an alternative method.
Reference Range
Negative
Specifications
- EQA Scheme?: Yes
-
EQA Status:
UK NEQAS for General Autoimmune serology.