Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
Turnaround Time
14 daysSample Stability
Stable at between 2C and 8C up to 14 daysLiver antibodies
General Information
The EUROLINE Autoimmune Liver disease profile measures human IgG autoantibodies to 9 different antigens: AMA-M2, M2-3E, Sp100, PML, gp210, LKM-1, LC-1, SLA/LP and Ro-52, in serum or plasma. It is largely used in the diagnosis of autoimmune liver diseases, such as primary biliary cirrhosis, primary sclerosing cholangitis, suspected autoimmune hepatitis or where there is an increase in transaminases for unclear reasons.
Notes
|
Autoantibody |
Clinical Relevance |
|
AMA-M2 |
Has a prevalence of approximately 85-95% in PBC. It is also seen in 30-96% of overlap-syndrome cases. |
|
M2-3E |
Occur with a prevalence of 90-95% in PBC cases. Also found in AIH patients with a prevalence of 4%. |
|
Sp100 |
Detected in PBC patients with a prevalence of 15-31%. |
|
PML |
Associated with PBC (prevalence 13%) and AIH (prevalence 4%). |
|
Gp210 |
Detected with a prevalence of 26% in PBC and 4% in AIH. |
|
LKM-1 |
Has a prevalence of around 70% in AIH Type 2. |
|
LC-1 |
Detected in approximately 10% of AIH Type 1 and 35% of AIH Type 2 patients. |
|
SLA/LP |
Found in AIH patients with a prevalence of 15-30% (Europe, North America) and 7% (Japan). |
|
Ro-52 |
Has a prevalence of 5-19% in AIH. Not specific for autoimmune liver disease and can be found in sera from patients with myositis, SSc and other collagenoses. |
Reference Range
Interperative assay , results reported as positive, negative or equivocal.
Source of Reference Range
Provided by Euroimmune ( kit manufacturer, references detailed in kit insert)Specifications
- EQA Scheme?: Yes
- EQA Status: UKNEQAS for General Autoimmune Serology