Gabapentin (Neurontin)

General Information

Gabapentin is a lipophilic GABA analogue designed to be a GABA agonist. It is useful in partial seizures: simple, complex or partial with secondary generalised tonic-clonic seizures. The mechanism of action is unknown but may be through release of GABA. It has also been used in migraine and in chronic pain relief.

Side effects of gabapentin use may include fatigue, somnolence, ataxia and dizziness. Weight gain may be seen in chronic therapy. Abrupt withdrawal of therapy should be avoided.

Gabapentin is also abused, producing feelings of relaxation, calmness and euphoria. Some users have reported that the ‘high’ from snorted gabapentin can be similar to taking a stimulant. Gabapentin may also enhance the euphoric effects of other drugs, like opiates, and is likely to increase the risks when taken in this way.

Therapeutic drug monitoring is not recommended due to wide range of clinically effective serum concentrations and a low incidence of toxicity. However, blood measurement may be used to adjust dosing during renal failure or to assess compliance.