C3N
Preferred Sample Type
Suitable Specimen Types
- Serum
2mL serum
Sample Processing in Laboratory
First Class Post to ref. lab.
Sample Preparation
NULL
Turnaround Time
2-4 weeksSample Stability
NULL
C3 Nephritic factor
General Information
C3 nephritic factor is an IgG antibody which stabilises the alternative pathway C3 convertase leading to continuous C3 breakdown. If positive in patient with renal disease it strongly sugests mesangio-capillary nephritis. Approx two thirds of patients with partial lipodystrophy have a low C3 and circulating C3 nephritic factor, and have an increased tendency to develop mesangio-capillary nephritis. Clinical utility - MPGN Type II, familial lipodystrophy, transiently in post-streptococal glomerulonephritis.
Patient Preparation
None
Notes
This test is only indicated if the C3 concentration is low
Reference Range
Negative
Specifications
- EQA Scheme?: No
-
EQA Status:
No EQA scheme available