C1q
Preferred Sample Type
Suitable Specimen Types
- Serum
2ml serum
Specimen Transport
2mL Serum (Gel 5mL Yellow tube). Transport fresh or freeze within <7hrs.y
Sample Processing in Laboratory
Sent Frozen to referral laboratorySample Preparation
Freeze within 7 hours of venepunctureTurnaround Time
Up to 20 days from receipt at Referral LaboratorySample Stability
C1q
General Information
C1q is the initiating molecule for the classical activation pathway of complement. Deficiencies or defects in the molecule lead to a reduced or absent CH50 value. Familial deficiency is rare but reduced levels may be associated with SLE, recurrent bacterial infections and with glomerulonephritis. C1q levels are usually only measured in cases where CH50 is absent or the patient has increased susceptability to infection. The exception to this is in the identification of the consumptive defect in acquired angioedema, where levels are almost always low
Reference Range
Supplied by reference laboratory
50-250 mg/L
Source of Reference Range
Collaborative study between reference laboratory and PRUSpecifications
- EQA Scheme?: No
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EQA Status:
No EQA scheme available