Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
Specimen Transport
First class postSample Processing in Laboratory
Place sample in toxicology rack.Sample Preparation
None requiredTurnaround Time
3 days.Sample Stability
Keep refrigerated. 4 degrees.Bisoprolol
General Information
Bisoprolol is a synthetic beta-adrenergic blocking agent that has been used clinically since 1984 for the treatment of hypertension. It is available as the hemifumurate salt in 2.5 - 10 mg tablets for oral administration, occasionally in combination with hydrochlorothiazide. The usual adult dose is 5 - 10 mg daily.
Side effects during bisoprolol therapy include nausea, vomiting, diarrhoea, weakness and fatigue. Several patients survived acute overdosage with up to 2000 mg of the drug after experiencing bradycardia and/or hypotension.
Patient Preparation
For TDM, sample should be taken prior to dose. If toxicity is suspected, take sample at earliest opportunity
Notes
Bisoprolol measured by HPLC-DAD.
Please note this assay is not currently UKAS accredited
Reference Range
Therapeutic range: 0.01 - 0.1 mg/L. (Schulz et al. Critical Care 2012, 16:R136).
Specifications
- EQA Scheme?: Yes
- EQA Status: LGC QUARTZ, LGC CLIN TOX