Local code : PI
Preferred Sample Type
Suitable Specimen Types
- Serum
1 mL
Sample Processing in Laboratory
Usual
Sample Preparation
Samples must be clot-free, should not be haemolysed and should be free of any other particles.
Turnaround Time
14 daysSample Stability
Alpha-1-Antitrypsin (A1AT or AAT) Phenotyping
General Information
Some indications: Indicated where A1AT levels are below median for age. Alpha 1 antitrypsin deficiency is associated with liver disease and pulmonary emphysema. A1AT is a glycoprotein and a part of a family of protease inhibitors that control various inflammatory cascades. Genetic variants of A1AT are characterisedby their different electrophoretic mobilties i.e. M, S or Z. Z and S variants have decreased synthesis of A1AT. S forms produce 60-80% of normal and Z produces only 15% of normal.Normal range is age related.
Patient Preparation
None
Notes
None Given
Reference Range
M pattern
Specifications
- EQA Scheme?: Yes
-
EQA Status:
EQA scheme run by UKNEQAS