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Department

Biochemistry

Preferred Sample Type

Urine Uric Acid (Urate)
24 hour collection

Sample Processing in Laboratory

Usual

Sample Preparation

Usual

Turnaround Time

1 Day

Sample Stability

4 ºC

Urine Uric Acid (Urate)

General Information

Uric acid (urate) is the final metabolite of endogenous and dietary purine nucleotide metabolism. It is the product of xanthine oxidase–catalyzed conversion of xanthine and hypoxanthine.

Hyperuricaemia may occur due to increased formation of uric acid due to primary causes such as inherited metabolic diseases or secondary causes such as increased intake, increased nucleic acid turnover (e.g. in leukemia, myeloma or chemotherapy) or tissue hypoxia. It may also occur due to decreased excretion due to AKI, CKD or preeclampsia. Asymptomatic hyperuricaemia is frequently detected via biochemical screening. Long-term follow up of these patients should be undertaken because many are at risk of kidney disease as a result of hyperuricaemia and hyperuricuria. Few of these patients ever develop the clinical symptoms of gout, a systemic disease caused by the buildup of uric acid in the joints

Hypouricaemia is much less common than hyperuricaemia and may be due to severe hepatocellular disease, defective renal tubular absorption of uric acid (e.g. in Fanconi syndrome) or over-treatment with allopurinol, 6-mercaptopurine or azothioprine. Very rarely hypoyricaemia may be to an inherited metabolic defect, such as those which cause a xanthine oxidase deficiency.

Urinary uric acid measurement, together with serum uric acid, should be perfored in stone formers as hyperuricuria is a risk factor for the formation of both uric acid stones and calcium stones.

Patient Preparation

None

Notes

Please note, from 22/7/19 analysis performed using Abbott Alinity analyser.   The test is awaiting UKAS accreditation.

Reference Range

1.5-4.5 mmol/24 hours

Source : Pathology Harmony Recommendations

Specifications

  • EQA Scheme?: Yes
  • EQA Status:

    RIQAS