Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
Specimen Transport
UsualSample Processing in Laboratory
Centrifuge and place in toxicology box in cold room.Sample Preparation
CentrifugeTurnaround Time
3 working daysSample Stability
4 ºCParoxetine
General Information
Paroxetine (Paxil, Pexeva, Seroxat) is a serotonin reuptake inhibitor, belonging to a class of drugs which contains fluoxetine and sertraline and has been used since 1978 as an antidepressive agent.
Adverse reactions for paroxetine include somnolence, agitation, tremor, insomnia, nausea and muscular weakness. Concurrent administration of a monoamine oxidase inhibitor may cause extreme agitation, muscle rigidity, hyperthermia, hypertension, delerium and coma (the serotonin syndrome). Hepatotoxicity may occur with therapeutic usage and severe neuroleptic malignant syndome has been described. Vertigo, nausea and comiting have been reported in patients following discontinuation of paroxetine therapy.
Patient Preparation
For TDM, sample should be taken prior to dose. If toxicity is suspected, take sample at earliest opportunity
Notes
Please avoid use of gel seperator tubes.
Reference Range
Therapeutic range = 20 - 65 ug/L
Please contact the laboratory if paroxetine measurement is required for therapeutic monitoring purposes.
Paroxetine is measured by LC-MS/MS.
Specifications
- EQA Scheme?: Yes
- EQA Status: LGC QUARTZ, LGC CLIN TOX