Preferred Sample Type
Suitable Specimen Types
- Plain Spot Urine
Sample Processing in Laboratory
Usual
Sample Preparation
Usual
Turnaround Time
1 daySample Stability
Samples are stable for seven days at 4 ºC, freeze samples at -20 ºC for long term storage.
Creatinine (Urine)
General Information
Creatinine is a non-protein waste product of creatine phosphate metabolism by skeletal muscle tissue. Creatinine production is continuous and is proportional to muscle mass. Serum creatinine concentrations are used in the determination of creatinine clearance (an indicator of GFR) and estimation of the GFR utilising the 4 variable MDRD equation. Each of these derived figures can then be used to both identify and monitor chronic kidney disease. Determination of urine creatinine is useful in:
- The measurement of creatinine clearance which also requires measurement of creatinine in serum. (Requires 24 hour urine collection)
- Determination of the albumin/creatinine ratio (ACR) in testing for microalbuminuria (requires plain spot urine)
- To compensate for variations in urine concentration in spot-check and 24 hour samples, it is helpful to compare the amount of the analyte of interest to its concentration of creatinine
From Monday 10th September 2018 creatinine will be measured using the enzymatic creatinine method.
For further information on how this will effect your results please refer to:
http://www.heftpathology.com/alphaindex/downloads/n.html
Enzymatic creatinine is currently not a UKAS accredited test. It will be assessed in October 2018.
Patient Preparation
None
Notes
Estimation of creatinine clearance requires a 24 hour urine sample and paired serum creatinine sample.
Please note, from 22/7/19 analysis performed using Abbott Alinity analyser. The test is awaiting UKAS accreditation.
Reference Range
Male: 5.1-14.2 mmol/L 7.7-21.3 mmol/24hrs
Female: 3.9-9.4 mmol/L 5.9-14.1 mmol/24hrs
Source of Reference Range
Abbott DiagnosticsSpecifications
- EQA Scheme?: Yes
-
EQA Status:
NEQAS for Urine Chemistries