Preferred Sample Type

17 alpha hydroxyprogesterone (17OHP)

Suitable Specimen Types

  • Serum
  • Li Hep Plasma
1 mL blood (4 x paed Lith Hep tubes)

Specimen Transport

Put on daily transport to referral lab

Sample Processing in Laboratory

Usual sample transport

Sample Preparation

Centrifuge on receipt

Turnaround Time

1 week

Sample Stability

No special storage conditions

17 alpha hydroxyprogesterone (17OHP)

General Information

17alpha-Hydroxyprogesterone is an intermediate in the biosynthesis of cortisol. Deficiency of either 11- or 21-hydroxylase activities leads to an increased concentration of 17alpha-hydroxyprogesterone in the peripheral circulation. This test is less valuable in 11-hydroxylase deficiency, where 11-deoxycortisol is the analyte of choice. 'Functional' deficiencies of 21-hydroxylase and 11-hydroxylase have been described. Indications: a) Diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. b) Monitoring the response to corticosteroid therapy in congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 3) Identification of heterozygotes for congenital adrenal hyperplasia and diagnosis of mild congenital adrenal hyperplasia (also referred to as late-onset and cryptic forms).

Patient Preparation

Time of collection MUST be stated.

 

 

 

Notes

Lithium Heparin samples ok for paediatric samples. If urgent requests required contact reference lab, bleep 1417.

Reference Range

Age Dependant

Neonates (>48 hrs): <8nmol/L. For neonates please record gestational age, birth weight and sex. Premature or small babies can have inappropriately high values.

Adult males: 1.2 - 3.7 nmol/L.

Adults females: 0.6 - 4.0 nmol/L (follicular phase) and 1.0 - 6.0 nmol/L (luteal phase).

Paediatrics

Neonates: <8.0 nmol/L

Female & male Tanner stage 1: <5.0 nmol/L

Tanner Stage 1 Males/Females:  <5.0 nmol/L

Source of Reference Range

Regional Endocrine lab UHB

Specifications

  • EQA Scheme?: Yes
  • EQA Status: Enrolled in EQA scheme

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The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

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