MIRTAZ
Preferred Sample Type
Suitable Specimen Types
- Serum
- EDTA Plasma
- Li Hep Plasma
A minimum of 500 µl of plasma/serum is required.
Specimen Transport
First class postSample Processing in Laboratory
Place sample in toxicology rack.Sample Preparation
None requiredTurnaround Time
3 days.Sample Stability
Keep refrigerated. 4 degrees.Mirtazapine
General Information
Mirtazapine is a tetracyclic piperazinoazepine compound that has been used clincally as an antidepressant since 1994. Adult doses are normally in the a range of 15 - 45 mg once daily.
Adverse effects associated with mirtazapine therapy include somnolence, dizziness, agitation, hypertension and loss of appetite. Overdosage may cause disorientation, drowsiness and tachycardia.
Patient Preparation
For TDM, sample should be taken prior to dose. If toxicity is suspected, take sample at earliest opportunity
Notes
Mirtazapine is measured by LC-MS/MS.
Reference Range
Therapeutic range = 30 -80 ug/L
Desmethylmirtazapine does not contribute to pharmacological actions.
Specifications
- EQA Scheme?: Yes
- EQA Status: LGC QUARTZ, LGC CLIN TOX