Preferred Sample Type
CSF: 100 uL. Plasma: 100 uL (both min.vol.)
Sample Processing in Laboratory
As per usual requestSample Preparation
Red cells in CSF need to be separated and blood should be centrifuged to separate plasma. Both should then be frozen.Turnaround Time
2 weeksSample Stability
Supernatants need to be frozenGlycine in CSF and Blood (to be done simultaneously)
General Information
Analysis of glycine in CSF and a paired plasma specimen is performed for the diagnosis of non-ketotic hyperglycinaemia. In this disorder, CSF glycine concentration is usually significantly higher than the normal upper limit (20 umol/L) and the ratio of CSF:plasma glycine is generally > 0.09 (normal < 0.04)
Patient Preparation
none specific
Notes
CSF and lithium heparin (CSF and blood glycine to be done simultaneously) Both blood and CSF required
Reference Range
Provided by reference laboratory
Specifications
- EQA Scheme?: Yes
- EQA Status: No scheme available