Department

Toxicology

Preferred Sample Type

Quetiapine

Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
A minimum of 50 µl of plasma/serum is required.

Sample Processing in Laboratory

Place sample in toxicology rack.

Sample Preparation

None required

Turnaround Time

3 days.

Sample Stability

Keep refrigerated. 4 degrees.

Quetiapine

General Information

Quetiapine is a dibenzothiazepine derivative, structurally related to cloazapine which has been used clinically since 1997 as a neuroleptic agent in the treatment of psychosis. Daily doses may range from 150 - 800 mg and are usually administered in 2 - 3 portions. 

Adverse reactions to quetiapine therapy include somnolence, hypertension, dizziness, dry mouth and dyspepsia. Neuroleptic malignant syndrome has also been reported.

Patient Preparation

For TDM, sample should be taken prior to dose. If toxicity is suspected, take sample at earliest opportunity

Notes

Quetiapine measured by LC-MS/MS.

 

Reference Range

Therapeutic range: 100 - 500 μg/L. Toxicity associated with concentrations >1000 μg/L. (Schulz et al. Critical Care 2012, 16:R136).

Specifications

  • EQA Scheme?: Yes
  • EQA Status: LGC TDM

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The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

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