Department

Toxicology

Preferred Sample Type

Olanzapine

Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
50 ul of plasma or serum.

Sample Processing in Laboratory

Usual

Sample Preparation

Centrifuge. Place in toxicology box in cold room.

Turnaround Time

5 working days

Sample Stability

4 ºC

Olanzapine

General Information

Olanzapine (Zyprexa, Lilly) is an atypical antipsychotic agent with structural similarities to clozapine. It has high affinity for dopamine D1, D2, D4, 5HT2A, 5HT2C, 5HT3, a1-adrenergic, histamine H1 and five subtypes of muscarinic receptors and has been shown to improve both the positive and negative symptoms of schizophrenia. Dose-related side effects associated with olanzapine may include somnolence, weight gain, dizziness, peripheral oedema, and postural hypotension. Oral olanzapine is well absorbed. Olanzapine is extensively metabolised and distributed throughout the body, although the principal metabolites are thought to lack pharmacological activity. No metabolites accumulate in plasma on chronic dosage. Dosage is normally 5-20 mg/d (BNF recommended limit), but some patients are given up to 60 mg/d.

Mean plasma olanzapine half-lives are longer in elderly patients (65 y or more) (51.8 hr) as compared to adults (33.8 hr) and in females (36.7 hr) as compared to males (32.3 hr).

Olanzapine assay can be useful to:

  • Assess adherence
  • Assess adequacy of dosage
  • Investigate suspected acute poisoning

Patient Preparation

Take the sample 12 hours after dosage to aid interpretation of the result.

Please write dosage and times on request form.

Notes

Please avoid use of gel seperator tubes.

Analysed by LC-MS/MS

Reference Range

Therapeutic range 20 – 80 μg/L. Toxicity associated with concentrations >150 μg/L.

Specifications

  • EQA Scheme?: Yes
  • EQA Status: LGC TDM

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Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

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