Department

Biochemistry

Preferred Sample Type

Oestradiol

Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
1 mL blood (0.5 mL absolute minimum)

Sample Processing in Laboratory

Usual

Sample Preparation

Centrifuge

Turnaround Time

1 Day

Sample Stability

4 'C

Oestradiol

General Information

Oestrogens are responsible for the development of secondary female sex characteristics and are involved in the control of the female reproductive process.

Oestradiol levels are used to evaluate ovarian function and to help diagnose the cause of precocious puberty in girls (very early signs of puberty) and gynaecomastia in men. Its main use has been to help diagnose the reason for amenorrhoea (for example, to determine whether the cause is menopause, pregnancy, or a medical problem). In treatment of sub-fertility, repeated measurements are used to follow follicle development in the ovary in the days prior to in-vitro fertilisation. Oestradiol may also be used to monitor menopausal hormone replacement therapy, if given as 17-oestradiol by implant.

Patient Preparation

None

Notes

Please note, the drug Mifepristone may interfere/crossreact with the Abbott Oestradiol assay leading to falsely elevated results.  This applies to patients currently being treated with or recently treated with the drug Mifepristone, and patients should be not tested for up to two weeks based on information available regarding Mifepristone’s bioavailability

Reference Range

Male: 92 - 161 pmol/L

Female:

  Range (pmol/L)  
Follicular 92 921
Mid-Cycle Phase 140 2381
Luteal Phase 92 1145
Postmenopausal not on HRT <103
Postmenopausal on HRT <528

(Source: Abbott Diagnostics)

Specifications

  • EQA Scheme?: Yes
  • EQA Status:

    NEQAS and WEQAS

Copyright heftpathology 2013, 2014, 2015, 2016, 2017, 2018

HTA licence number is 12366

Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

UKAS Logos