Suitable Specimen Types

  • Plain Spot Urine
5 mL urine

Specimen Transport

Send frozen

Sample Processing in Laboratory

Protect Sample from light

Sample Preparation

Centrifuge and store at -20 ºC

Turnaround Time

14 days

Sample Stability

-20 ºC

Neopterin

General Information

Neopterin, a pyrazolopyridine compound, is produced by macrophages after induction by interferon gamma and serves as a marker of cellular immune system activation. Measurable levels of neopterin have been detected in both the serum and urine of patients suffering from various types of malignancies and viral infections. Changes in neopterin concentrations in serum or urine can predict complications such as graft rejection in organ transplant recipients. Elevated neopterin levels are found in autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus (SLE). Neopterin levels can be used as prognostic predictors for certain types of malignancies. Measurement of neopterin levels has particular value for monitoring patients infected with immunodeficiency virus.

Neopterin is eliminated primarily in the urine, so evaluation of urinary neopterin levels may be useful in assessing activation of the cellular immunity system even in the absence of typical clinical symptoms, since a correlation has been observed with the course of diseases involving cellular immunity activation and urinary neopterin levels.

Patient Preparation

None

Notes

Correlates well with CD4/CD8 ratios. Increased levels of neopterin are found during impaired renal function and viral infection in transplant patients. Elevated levels are also indicators for conditions related to impaired cellular immunity.

Reference Range

Provided by Ref Lab

Specifications

  • EQA Scheme?: No
  • EQA Status: No scheme available

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Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

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