Lipoprotein lipase is bound to the vascular endothelial membranes, where it has access to lipids in the blood after absorption from the intestine. This lipase activity cleaves fatty acids from lipoproteins and clears chylomicrons from the blood.
Administration of the anticoagulant heparin releases these membrane-bound lipases into plasma, where they can be measured as post-heparin lipolytic activity. The release occurs within minutes of the IV heparin dose. The timing of the sample collection is important, to avoid confusion with pancreatic lipase.
Special preparations need to take place before collection of these samples. These instructions can be obtained from the Ref Lab prior to sample collection. Contact Duty Biochemist 2506 who will liaise with Reference Lab.
(Withdraw blood 12 min post heparin; 70U/kg)
DB: Special instructions for collection of samples can be obtained from Reference Lab.
Investigation of hypertriglyceridaemia; diagnosis of lipoprotein lipase deficiency
The laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital form part of the services provided by University Hospitals Birmingham and are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/
Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.
For further test information, please visit the test database: http://www.heftpathology.com/frontpage/test-database.html.
Protection of personal information - Laboratory Medicine comply with the Trust Data Protection policy and have procedures in place to allow the Directorate and its employees to comply with the Data Protection act 1998 and associated best practice and guidance.
For further information contact Louise Fallon, Quality Manager, 0121 424 1235