Department

Toxicology

Preferred Sample Type

Lamotrigine (Lamictal)

Suitable Specimen Types

  • Serum
  • EDTA Plasma
  • Li Hep Plasma
100 ul serum/plasma

Sample Processing in Laboratory

Centrifuge and place in toxicology box in cold room.

Sample Preparation

Usual

Turnaround Time

5 working days

Sample Stability

4 ºC

Lamotrigine (Lamictal)

General Information

Lamotrigine is indicated for the treatment of partial and generalised seizures in adults and increasingly, in children. It may also have a role in the treatment of conditions such as Parkinson's disease. Adverse reactions are relativel minor, for example: (nausea, headache and dizziness). A typical dosage for Lamotrigine is 200-400 mg. bd; a therapeutic range of 1.0-4.0mg/L has been proposed by Wellcome. The half-life of the drug is around 24hours; although this is affected by concomitant therapy. Lamotrigine is known to delay the metabolism of carbamzepine and may also interact with other drugs. There is no therapeutic range for Lamotrigine and the tentative therapeutic range of 1-4 mg/L is suggested but this may be of limited value.

Patient Preparation

Trough specimen taken pre-dose or minimum 6hrs post-dose

Reference Range

Therapeutic range (epilepsy): 1 - 4 mg/L

Maximum drug efficacy (bipolar disorder): 3 - 14 mg/L

 

Specifications

  • EQA Scheme?: Yes
  • EQA Status: NEQAS TDM

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Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

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