Preferred Sample Type
Specimen Transport
Standard transport to laboratoryTurnaround Time
7 daysSample Stability
4 hoursEdoxaban Assay
General Information
Edoxaban is one of the direct oral anticoagulants, exerting an anticoagulant effect by inhibiting activated factor X.
Changes in the prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT) may be observed in patients on therapeutic edoxaban doses. However, these changes tend to be small, unpredictable, and highly variable, so clinicians should not use these markers to monitor the anticoagulant effects or titrate the dose of edoxaban (Plitt A, Giugliano RP. Edoxaban: review of Pharmacology and key phase I to III clinical trials. J Cardiovasc Pharmacol Ther. 2014;19(5):409–416)
Notes:
Urgent requests should be discussed with the laboratory prior to receiving the sample.
Notes
Urgent requests should be discussed with the laboratory prior to receiving the sample
Reference Range
Edoxaban is reported as ng/mL
For patient’s receiving 60mg edoxaban, peak plasma levels have been recorded as appox. 125-245 ng/ml for stroke prevention in NVAF, and appox. 149-317ng/ml for treatment of PE/VTE.1
For patient’s receiving 30mg edoxaban, peak plasma levels have been recorded as 60-120ng/ml2
1. ‘ICSH Recommendations for Laboratory Measurement of Direct Oral Anticoagulants’, Gosselin et.al, Thromb Haemost 2018’
2. Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation’ Weitz et al, Thromb Haemost 2010
Specifications
- EQA Scheme?: No
The laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital form part of the services provided by University Hospitals Birmingham and are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/
- Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217
- United Kingdom Health Security Agency laboratory is a UKAS accredited medical laboratory No.8213
Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.
For further test information, please visit the test database: http://www.heftpathology.com/frontpage/test-database.html.
Protection of personal information - Laboratory Medicine comply with the Trust Data Protection policy and have procedures in place to allow the Directorate and its employees to comply with the Data Protection act 1998 and associated best practice and guidance.
For further information contact Louise Fallon, Quality Manager, 0121 424 1235
