Department

Haematology

Preferred Sample Type

Edoxaban Assay

Specimen Transport

Standard transport to laboratory

Turnaround Time

7 days

Sample Stability

4 hours

Edoxaban Assay

General Information

Edoxaban is one of the direct oral anticoagulants, exerting an anticoagulant effect by inhibiting activated factor X.

Changes in the prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT) may be observed in patients on therapeutic edoxaban doses. However, these changes tend to be small, unpredictable, and highly variable, so clinicians should not use these markers to monitor the anticoagulant effects or titrate the dose of edoxaban (Plitt A, Giugliano RP. Edoxaban: review of Pharmacology and key phase I to III clinical trials. J Cardiovasc Pharmacol Ther. 2014;19(5):409–416)

Notes:

Urgent requests should be discussed with the laboratory prior to receiving the sample.

Reference Range:

Weitz et al (Thromb Haemost 2010; 104: 633-641) report levels of edoxaban in plasma as follows: for 30mg/day dosing, trough levels 5-20ng/ml, peak levels 60-120ng/ml. For 60mg/day dosing, trough levels 10-40ng/ml, peak levels 120-250ng/ml.

This test will be reviewed by UKAS for ISO 15189 accreditation at the next surveillance visit in October 2019

Notes

Urgent requests should be discussed with the laboratory prior to receiving the sample

Reference Range

Weitz et al (Thromb Haemost 2010; 104: 633-641) report levels of edoxaban in plasma as follows: for 30mg/day dosing, trough levels 5-20ng/ml, peak levels 60-120ng/ml. For 60mg/day dosing, trough levels 10-40ng/ml, peak levels 120-250ng/ml.

Specifications

  • EQA Scheme?: No

Copyright heftpathology 2013, 2014, 2015, 2016, 2017, 2018

HTA licence number is 12366

Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

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