Department

Haematology

Preferred Sample Type

Apixaban
2.7 ml

Specimen Transport

Standard transport to laboratory

Turnaround Time

7 days

Sample Stability

4 hours

Apixaban

General Information

Apixaban is a direct factor Xa inhibitor. It is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes mellitus, or symptomatic heart failure. Apixaban and other newer anticoagulants (dabigatran and rivaroxaban) appear equally effective as warfarin in preventing non-hemorrhagic stroke in people with atrial fibrillation and are associated with lower risk of intracranial bleeding.

Notes

Urgent requests should be discussed with the laboratory prior to receiving the sample

 

Reference Range

Apixaban is reported as ng/mL

For patient’s receiving 5 mg BD apixaban, peak plasma levels have been recorded as appox. 91-321 ng/ml for stroke prevention in NVAF, and appox. 59-302 ng/ml for treatment of PE/VTE.1

For patient’s receiving 2.5 mg BD Apixaban, peak plasma levels have been recorded as appox. 30-153ng/ml2

  1. ‘ICSH Recommendations for Laboratory Measurement of Direct Oral Anticoagulants’, Gosselin et.al, Thromb Haemost 2018’

The laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital form part of the services provided by University Hospitals Birmingham and are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217
  • United Kingdom Health Security Agency laboratory is a UKAS accredited medical laboratory No.8213

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://www.heftpathology.com/frontpage/test-database.html.

Protection of personal information - Laboratory Medicine comply with the Trust Data Protection policy and have procedures in place to allow the Directorate and its employees to comply with the Data Protection act  1998 and associated best practice and guidance.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

UKAS HEFT