Department

Immunology
Local code : ACL, B2GP1

Preferred Sample Type

anti Cardiolipin antibody + Anti Beta 2 glycoprotein

Suitable Specimen Types

  • Serum
5-10 ml

Sample Processing in Laboratory

Usual

Sample Preparation

usual

Turnaround Time

7

Sample Stability

stored at 4oC

anti Cardiolipin antibody + Anti Beta 2 glycoprotein

General Information

Some clinical indications:- one or more clinical episodes of arterial, venous or small vessel thrombosis.

One or more unexplained deaths of morphologically normal fetus at or beyond the 10th week of pregnancy.

 

Notes

Both Anti Cardiolipin and Beta 2 Glycoprotein 1 are useful in the assesment of risk of thrombosis in patients with SLE or related disorders, for monitoring of patients at risk for foetal loss.

Raised anti-cardiolipin and/or B2GP1 abs (IgM/IgG) on 2 occasions at least 12 weeks apart satisfies one of the criteria for a diagnosis of Anti Phospholipid syndrome
 

Reference Range

Consider IgG Anti cardiolipin antibody abnormal only if >23.8 U/mL

                     IgM Anti cardiolipin antibody abnormal only if >29.9 U/mL

(99th centile of normal), present on two or more occasions,
at least 12 weeks apart.

Consider IgG B2GP1 abnormal only if >17.7 U/ml

IgM B2GP1 abnormal only if >5.7 U/mL
(99th centile of normal), present on two or more occasions,
at least 12 weeks apart.

 

Specifications

  • EQA Scheme?: Yes
  • EQA Status:

    UK NEQAS scheme for Phospholipid antibodies

The laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital form part of the services provided by University Hospitals Birmingham and are UKAS (United Kingdom Accreditation Service) accredited to the ISO 15189:2012 standard. For a list of accredited tests and other information please visit the UKAS website using the following link: https://www.ukas.com/find-an-organisation/

  • Heartlands, Good Hope and Solihull Hospital pathology laboratories are a UKAS accredited medical laboratory No.8217
  • United Kingdom Health Security Agency laboratory is a UKAS accredited medical laboratory No.8213

Tests not appearing on the UKAS Schedule of Accreditation currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further test information, please visit the test database: http://www.heftpathology.com/frontpage/test-database.html.

Protection of personal information - Laboratory Medicine comply with the Trust Data Protection policy and have procedures in place to allow the Directorate and its employees to comply with the Data Protection act  1998 and associated best practice and guidance.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

UKAS HEFT