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Molecular Pathology

A molecular biology service is offered to aid in the diagnosis of lymphoproliferative disorders. PCR (Polymerase Chain Reaction) for IGH (Immunoglobulin heavy chain) and TCR (T cell receptor) clonality testing is performed using BIOMED-2 reagents.   

DNA can be extracted from formalin fixed paraffin embedded tissue, fresh tissue or blood.

Clonality tests available:

  • IGH rearrangement
  • TCRB gene rearrangement
  • TCRG gene rearrangement

Sample requirements:

  • Fresh tissue minimum 5mm3 for molecular studies (can be sent dry or in saline).
  • Representative formalin fixed paraffin embedded tissue blocks.
  • 5µm unstained paraffin sections.
  • 5-10 ml peripheral blood in EDTA.

Please see Labelling and completion of request form for guidence on specimen labelling.

The molecular biology service participates in the UK NEQAS Leucocyte immunophenotyping IGH/TCR clonally programme.


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Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

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