Guidance on Testing for Paroxysmal Nocturnal Haemoglobinuria
Paroxysmal Nocturnal Haemoglobinuria (PNH) is an acquired haematopoietic stem cell disorder resulting in a partial or total deficiency of proteins normally linked to cell membranes by a glycosylphosphatidylinositol (GPI) anchor. Classical features are;
- intravascular haemolysis
- bone marrow failure
- thrombotic tendency
- may also include abdominal pain, dysphagia, erectile dysfunction, renal failure, lethargy
It can often go undiagnosed for months or even years. Flow cytometry can provide a definitive diagnosis.
Click here for further guidance on PNH testing. Contact the laboratory on 0121 424 0704.