Changes in Renin and Aldosterone Service

Due to difficulties in obtaining sufficient kit supplies for our Renin workload, it is with regret that we will no longer be able to offer the measurement of Renin, and subsequently Aldosterone , from this laboratory.

We have been working closely with our colleagues at University Hospital Birmingham (UHB) and will be sending work there from the 28/2/2018. The Renin assay provided by UHB is an Immunoassay method (IDS iSYS) for renin mass with reference ranges comparable to the ones used at Heartlands.  See attached information.  The aldosterone method is a comparable assay by LC/MSMS.

The UHB laboratory is a UKAS accredited laboratory.  The aldosterone assay is already UKAS accredited and the Renin immunoassay will be assessed by UKAS as part of their next extension to scope application.

The aldosterone assay is in essence identical to the one used at Heartlands. It is a mass spec method and should have the same characteristics. The http://www.heftpathology.com/item/aldosterone.html information should be applicable.

There will be a slight change in the ratio cut offs used to take into account the renin method. We will be using the Endocrine guidelines ranges and use the 91 cut off with and Aldosterone greater than 750 as a “screen” positive interpretation. This is taken from the Endocrine guidelines on the investigation of Conns. https://academic.oup.com/jcem/article/93/9/3266/2596343

From a sample processing point of view continue to send the samples to Heartlands and we will  transport the samples to UHB.

Please contact the lab or duty biochemist if you have any queries

Categories: Biochemistry

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