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Clinical Services (Haematology)

Inpatient referrals are by telephone to the haematology doctor on - call or in writing to a haematology consultant.

Haematology Outpatients

Haematology clinics are held on all 3 sites of the trust and at the community hospitals in Lichfield and Tamworth.  The larger clinics held at Heartlands and Good Hope have samples processed through a point of care analyser located on the unit.

Read more: Clinical Services (Haematology)

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Control of Anticoagulant Therapy

Prophylaxis

Heparin assays are not required routinely when 'low dose' subcutaneous heparin is used. They are available when dictated by a relevant clinical condition. The PTT is generally normal when low dose heparin is used.

The platelet count should be monitored in all patients on heparin as the drug may induce thrombocytopaenia. The use of any anticoagulant in pregnancy poses additional problems, which may require specialist advice.

Read more: Control of Anticoagulant Therapy

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D-Dimers

D-Dimer and Wells Score

This section relates to current practice at Good Hope Hospital only. Heartlands and Solihull only offer laboratory D-Dimer testing for patients with suspected disseminated intravascular coagulation or sepsis. For patients with suspected deep vein thrombosis or pulmonary embolism, the service is provided as a point of care test within the Emergency Departments.

D-Dimer is a marker of endogenous fibrinolysis and is often used as a non-diagnostic marker in patients suspected of having deep-vein thrombosis or pulmonary embolism. It is also an important part of screening for disseminated intravascular coagulation.

For ?DVT/PE D-Dimer should only be used in conjunction with pre-test probability (PTP) scoring (Wells score). It is essential that this PTP information is clearly stated on the request form together with the clinical details. Without this information the laboratory cannot perform the analysis.

One correctly filled sodium citrate (blue top) is required for this test.

 

Calculating the Wells Score

Deep Vein Thrombosis

Clincal Characteristic

Score

Active cancer (patient receiving treatment for cancer within the previous 6 months or currently receiving palliative treatment)

1

Paralysis, paresis, or recent plaster immobilisation of the lower extremities

1

Recently bedridden for 3 days or more, or major surgery within the previous 12 weeks requiring general or regional anaesthesia

1

Localised tenderness along the distribution of the deep venous system

1

Entire leg swollen

1

Calf swelling by more than 3 cm compared with the asymptomatic leg (measured 10 cm below the tibial tuberosity)

1

Pitting oedema confined to the symptomatic leg

1

Collateral superficial veins (non-varicose)

1

Previously documented DVT

1

Alternative diagnosis at least as likely as DVT

-2

 Score: 0 = Low probability, 1-2 = Intermediate probability, >3 = High probability

Pulmonary Embolism

Clincal Characteristic

Score

Clinical symptoms of DVT

3

Alternative diagnosis is less likely than PE

3

Heart rate >100 bpm

1.5

Immobilisation or surgery within the previous 4 weeks

1.5

Previous objectively diagnosed DVT/PE

1.5

Haemoptysis

1.0

Malignancy with treatment within 6 months or palliative

1.0

 

 Score: 0 = Low probability, 1-2 = Intermediate probability, >3 = High probability

 

Interpreting the Wells Score

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A negative DDimer can safely rule out DVT/PE if the PTP is low in an outpatient. A DDimer test is not necessary if the PTP is Intermediate or High, further appropriate investigations should be performed. 

Other information to consider

  • DDimer is of no use for patients developing suspected DVT/PE during hospitalisation and therefore the test should not be requested for inpatients. This would apply to a patient who was admitted for reasons other than suspected DVT or PE and did not have symptoms or signs suggestive of DVT/PE on admission.
  • DDimer is of no use in patients already on warfarin or heparin of LMWH, false negative results can be seen.
  • In pregnant women, DDimer is of questionable value and it is not recommended for use in the diagnosis of DVT/PE.

 

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HTA licence number is 12366

Protection of Personal Information – Laboratory Medicine comply with the Trust Data Protection Policy and have procedures in place to allow the Directorate and it’s employees to comply with the Data Protection Act 1998 and associated best practice and guidance.

The Trust Laboratories at Heartlands Hospital, Good Hope Hospital and Solihull Hospital were awarded UKAS (United Kingdom Accreditation Service) accreditation to the internationally recognised ISO 15189 standard in May 2015. For a list of accredited tests and other information please visit the test database http://www.heftpathology.com/frontpage/test-database.html.
Tests not appearing on this scope are either under consideration or in the process of accreditation and so currently remain outside of our scope of accreditation. However, these tests have been validated to the same high standard as accredited tests and are performed by the same trained and competent staff.

For further information contact Louise Fallon, Quality Manager, 0121 424 1235

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