A molecular biology service is offered to aid in the diagnosis of lymphoproliferative disorders utilising PCR (Polymerase Chain Reaction) and capillary gel electrophoresis for IGH (Immunoglobulin heavy chain) and TCR (T cell receptor) clonality testing. The demonstration of monoclonal lymphocyte populations supports lymphoma diagnosis. The PCR reactions are performed using Invivoscribe technologies IdentiCloneTM assays which were developed and validated by the Euroclonality/Biomed-2 group. DNA can be extracted from formalin fixed paraffin embedded tissue, fresh tissue or blood.
Clonality tests available :
The molecular biology service participates in the UK NEQAS Leucocyte immunophenotyping IGH/TCR clonality programme.